Joint Annual Meeting ISMRM-ESMRMB 2018

Joint Annual Meeting ISMRM-ESMRMB • 16-21 June 2018 • Paris, France

Weekend Educational Course
Basics of Perfusion Imaging

Basics of Perfusion Imaging: Part 1
Weekend Course

ORGANIZERS: Fernando Calamante, Hanzhang Lu, Steven Sourbron

Sunday, 17 June 2018

N03

08:00 - 09:28

Moderators: Laura Parkes, Ze Wang

Skill Level: Basic

Session Number: WE-16A

Overview
This half-day, basic course is designed for scientists and clinicians who want to learn about MR imaging of perfusion and related parameters. The course will begin with a description of the physiology of perfusion, followed by the acquisition and data processing of the main classes of perfusion imaging techniques (dynamic susceptibility contrast MRI, dynamic contrast enhanced MRI, and arterial spin labeling).

Target Audience
This course is designed for basic research scientists and clinicians. It is expected to provide attendees with an understanding of fundamental as well as practical aspects of perfusion MRI and a solid background upon which to base decisions about choice of perfusion imaging methods for their own applications.

Educational Objectives
As a result of attending this course, participants should be able to:
-Define and understand the relationships between perfusion and related parameters such as transit times, blood volume, capillary permeability, and interstitial volume;
-Describe the basic principles and assumptions underlying common tracer-kinetic analysis models for perfusion and permeability measurement;
-Describe how ASL principles can be used to measure physiological parameters beyond CBF;
-Assess which parameters each of the above methods are inherently sensitive to and why;
-Describe the key issues in the extraction of physiological parameters from ASL, DSC, and DCE data; and
-Identify the appropriate acquisition methods for perfusion and other related parameters.

08:00		Physiology of Perfusion Osamu Togao This presentation covers macro- and micro-anatomy of cerebral vasculature and the basic mechanism and physiology of cerebral perfusion.
08:22		DSC Acquisition & Reconstruction Ashley Stokes Dynamic susceptibility contrast (DSC) MRI methods provide valuable information regarding cerebral perfusion. In this talk, I will discuss current recommendations for best practices in clinical DSC-MRI acquisition and reconstruction. I will also highlight more recent technological advancements for DSC-MRI, along with the associated advantages and trade-offs of these methods. This talk will provide both a basic foundation for understanding current DSC-MRI protocols and insight into future directions for DSC-MRI acquisition and reconstruction.
08:44		DSC Post-Processing & Modeling (with Demo) Irene Mikkelsen Pivotal in the understanding of processing of Dynamic Susceptibility Contrast perfusion imaging, is the concept of the Residue Function. This function is the underlying tissue function, which is indepent on how the contrast agent is administered to the tissue. This presentation describes the inverse problem and two ways of solving it.
09:06		DCE Acquisition & Reconstruction Anders Garpebring This talk will describe the basics of dynamic contrast-enhanced (DCE) MRI with focus on the acquisition of the data. Key prerequisites for accurate quantification of perfusion parameters such as K^trans are sufficiently high spatial and temporal resolution but also accurate quantification of the contrast agent (CA) concentration. The basics of how this can be achieve will be covered in the talk.
09:28		Break & Meet the Teachers

Basics of Perfusion Imaging: Part 2
Weekend Course

ORGANIZERS: Fernando Calamante, Hanzhang Lu, Steven Sourbron

Sunday, 17 June 2018

N03

10:00 - 11:30

Moderators: Laura Parkes, Ze Wang

Skill Level: Basic

Session Number: WE-16B

Overview
This half-day, basic course is designed for scientists and clinicians who want to learn about MR imaging of perfusion and related parameters. The course will begin with a description of the physiology of perfusion, followed by the acquisition and data processing of the main classes of perfusion imaging techniques (dynamic susceptibility contrast MRI, dynamic contrast enhanced MRI, and arterial spin labeling).

Target Audience
This course is designed for basic research scientists and clinicians. It is expected to provide attendees with an understanding of fundamental as well as practical aspects of perfusion MRI and a solid background upon which to base decisions about choice of perfusion imaging methods for their own applications.

Educational Objectives
As a result of attending this course, participants should be able to:
-Define and understand the relationships between perfusion and related parameters such as transit times, blood volume, capillary permeability, and interstitial volume;
-Describe the basic principles and assumptions underlying common tracer-kinetic analysis models for perfusion and permeability measurement;
-Describe how ASL principles can be used to measure physiological parameters beyond CBF;
-Assess which parameters each of the above methods are inherently sensitive to and why;
-Describe the key issues in the extraction of physiological parameters from ASL, DSC, and DCE data; and
-Identify the appropriate acquisition methods for perfusion and other related parameters.

10:00		DCE Post-Processing & Modeling (with Demo) Jesper Kallehauge Post-processing and modeling of DCE time curves allow for reducing a vast amount of data into a set of parametric maps related to the underlying tissue properties: Permeability, Perfusion, compartmental composition etc. Multiple steps and methods are involved in reaching this point with possible pitfalls resulting in potential misinterpretation of the acquired data. Participants should come away from this seminar understanding these steps and how choices made during data acquisition influence what can sensibly be extracted from the data.
10:22		ASL Acquisition & Reconstruction Weiying Dai The lecture will cover the key components of arterial spin labeling (ASL) data acquisition and reconstruction, including basic principles, different labeling approaches, background suppression techniques to improve the temporal stability of ASL signals, advanced ASL techniques, readout options, and image reconstruction.
10:44		ASL Post-Processing & Modeling (with Demo) Michael Chappell The aim of this talk is to introduce the key steps involved in the analysis of ASL data to produce a perfusion-weighted image, a full quantified perfusion image and even images of other haemodynamic parameters. We will see that ASL analysis is for the most part quite simple and eve more advance methods are quite accessible through software tools that are now freely available.
11:06		ASL: Beyond CBF Peiying Liu This talk will cover advanced ASL-based techniques which provide quantitative measurements of hemodynamic and physiological parameters beyond brain perfusion measured in conventional ASL. Such advances include the implementation of different preparation and acquisitions modules, as well as comprehensive modeling of the signals. With these techniques, new hemodynamic and physiological parameters, including blood oxygenation, tissue transit time, arterial blood volume, vascular compliance, and water permeability of blood-brain barrier, can be obtained.
11:28		Adjournment & Meet the Teachers

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