27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Combined Educational & Scientific Session
Mapping the Liver

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Mapping the Liver
Combined Educational & Scientific Session

ORGANIZERS: Utaroh Motosugi, Mustafa Shadi Bashir

Monday, 13 May 2019
Room 510A-D  13:45 - 15:45 Moderators:  Bachir Taouli, Scott Reeder

Skill Level: Basic to Advanced

Session Number: M-07

Through rapid technical development, it is now possible to obtain quantitative maps of a variety of MR-related properties of the liver. Many of these correspond directly with important physical properties of the liver, such as R2* mapping for iron quantification and proton density fat fraction mapping for fat quantification. During this session, both technical developments and clinical applications in quantitative mapping in the liver will be presented.

Target Audience
MDs and PhD scientists interested in quantitative MRI techniques applied to the liver.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify emerging quantitative mapping techniques applied to the liver; and
- Discuss current and likely future clinical applications of quantitative mapping techniques in the liver.


Technical Development
Diego Hernando
This presentation will describe MRI-based techniques for quantification of fat and iron deposition in the liver. Specifically, this presentation will cover: 1) the relevant MR contrast mechanisms related to the presence of fat and iron, 2) the types of pulse sequences used to probe these contrast mechanisms, 3) the main challenges for quantification of fat and iron, 4) the technical solutions to these challenges, and 5) the state of the art of development and validation of MRI-based techniques for quantification of fat and iron deposition in the liver.  

Clinical Applications
Jeong Min Lee
New advances in liver MRI including T1-,T2*- and T1 rho mapping techniques, proton density fat fraction (PDFF) and elastography techniques may enable diagnosis of unseen pathologies by conventional techniques in the liver.  In addition, Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%). In the near future, MR fingerprinting may enable single slice acquisition and easy implementation of multiparametric MRI and follow-up of patients. These noninvasive imaging techniques serve an alternative or complimentary role to invasive liver biopsy. Mapping techniques of the liver, for fat, iron, and fibrosis quantitative imaging is increasingly being used in clinical practice, and may soon become standard of care. 

14:45-16:45   T.B.A.
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