27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Member-Initiated Symposium
Combined Diffusion-Relaxometry Microstructure Imaging

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Combined Diffusion-Relaxometry Microstructure Imaging
Member-Initiated Symposium

ORGANIZERS: Jana Hutter, Marco Palombo, Paddy Slator

Thursday, 16 May 2019
Room 513A-C  13:45 - 15:45

Session Number: MIS-22

Diffusion and relaxometry are the two most used MR contrasts in clinical diagnostics and prognostics. However, our understanding of the driving chemical-physical mechanisms underpinning complex systems such as biological tissues is still very limited. Even more challenging is the attempt to infer the link between diffusion and relaxation contrasts and the underlying tissue microenvironment. An important obstacle is that these contrasts influence each other. Thus, measuring them separately has limitations due to inherent correlations. Advanced MR techniques, generally called "multi-dimensional" have been recently proposed as very promising tools to selectively investigate these correlations and try to disentangle useful information about the tissue microstructure. In particular, this symposium will focus on combined diffusion-relaxometry MRI schemes because of their versatility and compatibility with current clinical setups.

The session will focus on:
1. What questions (basic/clinical research) can diffusion-relaxometry potentially answer?
2. What are the existing acquisition and analysis techniques?
3. What are the future directions?

The session will conclude with a panel discussion comprising all speakers. This would discuss important topics in this new field, including: minimizing acquisition times, data-driven vs. model-based analysis, main barriers to clinical translation.

Target Audience
Clinicians and scientists interested in the potential of combined diffusion-relaxometry to address unanswered questions in microstructure imaging.

Educational Objectives
As a result of attending this course, participants should be able to:
- Recall the historical context within which combined diffusion-relaxometry lies;
- Recognize the current state of the art acquisition and analysis techniques for combined diffusion-relaxometry;
- Identify the advantages and limitations of combined diffusion-relaxometry techniques; and
- Evaluate the multitude of potential clinical applications in the CNS and beyond.


  Open Questions for Diffusion & Relaxometry MRI
Karla Miller
  Theoretical Approaches for Combined Diffusion-Relaxometry
Carl-Fredrik Westin
  Exploiting B0 Field Strength as an Additional Dimension in Multi-Dimensional Diffusion MRI
Frederik Laun
  Multidimensional Diffusion-Relaxation Correlation Spectroscopic Imaging
Justin Haldar
  Use of Spectral Constraints in Multidimensional Diffusion-Relaxation Correlation MRI: Mapping Tissue
Dan Benjamini
  Characterization of Prostate Microstructure Using Water Diffusion & NMR Relaxation
Gregory Lemberskiy
  Multidimensional Correlation of Nuclear Relaxation Rates & Diffusion Tensors
Joao Martins de Almeida
  Panel Discussion
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