27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Preclinical MRI: Methods & Applications: Neuroimaging

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Preclinical MRI: Methods & Applications: Neuroimaging
Sunrise Session

ORGANIZERS: Ed Wu, Elena Vinogradov, Lucio Frydman, Damian Tyler, Elena Kaye

Monday, 13 May 2019
Room 513A-C  07:00 - 08:00 Moderators:  Damian Tyler, Alex T. L. Leong

Skill Level: Intermediate

Session Number: S-M-03

Studies of animal models of human pathologies are critical for bridging research "from bench to bedside." Such studies are also essential for understanding the basic biological process and functions in humans. This course will first review the basic physical and biological aspects of in vivo animal MRI, then state-of-art neuroimaging, endogenous and exogenous contrasts, molecular and cellular imaging, and finally other animal imaging modalities including MR-PET and magnetic particle imaging (MPI).

Target Audience
Physicians, imaging scientists/engineers, medical physicists, technologists and other professionals with need for preclinical MR techniques to address transnational, clinical, and basic sciences questions.

Educational Objectives
As a result of attending this course, participants should be able to:
- Apply new MRI hardware and software to better assess small animal models of disease;
- Identify the strengths and limitations of preclinical MRI studies using specific MRI technologies, including MR-PET and MPI; and
- Design basic preclincial MRI experiments, including analyses and validation.


  Basic Brain MRI Methods
Kevin Chan
This session will review the basic settings of in vivo animal brain MRI across species. In addition, we will use the visual system as a model to introduce how preclinical MRI can help understand the basic biological process and functions in the brains from normal development to neurodegeneration, neuroprotection, neuroplasticity and neuroregeneration.

Advanced Brain MRI: Functions & Circuits
Joanes Grandjean
Functional Magnetic Resonance Imaging in rodents open new avenues to understand the mechanisms underlying distributed neuronal networks and their dynamics in the healthy and diseased brain. Here, I will review the major observations and current limitations associated with the method. I will present the results from the first multi-center mouse resting-state fMRI comparison and will highlights the needs for the adoption of standards in the field. 

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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.