27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Multinuclear Imaging & Spectroscopy: Electrolytes (Sodium & Beyond)

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Multinuclear Imaging & Spectroscopy: Electrolytes (Sodium & Beyond)
Sunrise Session

ORGANIZERS: Ronald Ouwerkerk, Wolfgang Bogner

Monday, 13 May 2019
Room 512A-H  07:00 - 08:00 Moderators:  Rob Stobbe, Manuela Rösler

Skill Level: Basic to Advanced

Session Number: S-M-05

This is the first course of a four-part sunrise educational series on multi-nuclear imaging and spectroscopy. This session will first review the existing MR imaging methods for 23Na-MRI and nuclei with similar MR properties such as 39K and 35Cl that are available for (clinical) research. It will then introduce emerging (clinical) applications to study cell membrane potentials and tissue integrity in healthy tissue, pathologic states, and as a way to monitor treatment response.

Target Audience
MR physicists and clinicians working with 23Na-MRI or planning to work with 23Na-MRI or similar nuclei.

Educational Objectives
As a result of attending this course, participants should be able to:
- Recognize the challenges of 23Na-MRI data acquisition;
- Recall a number of different 23Na-MRI acquisition schemes;
- Explain the pros and cons of various acquisition schemes; and
- Choose an acquisition scheme to suit a specific application.


  Understanding & Selecting Acquisition Methods for 23Na or 39K-MRI
Guillaume Madelin
In this presentation I will give an overview of the methods used to acquire sodium (23Na) and potassium (39K) MRI in vivo, and of their challenges and potential clinical applications.

  Clinical Applications of 23Na-MRI
Matilde Inglese
Over the last few decades, the advent of high and ultra-high field MRI and the growing availability of novel sequence acquisition schemes have led to substantial advances in sodium 23 (23Na) imaging and have rekindled interest in clinical applications. Advantages and disadvantages associated with the use of 23Na MRI will be discussed. The contribution of 23Na MRI to a better understanding of the pathophysiology of neurological diseases and the potential clinical impact of sodium measurements in terms of diagnosis and prognosis will also be discussed. Finally, future directions to pursue in this research field will be identified

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