27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Imaging Without Gadolinium: ASL

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Imaging Without Gadolinium: ASL
Sunrise Session

ORGANIZERS: Pia Maly Sundgren, Elna-Marie Larsson, Robert Witte

Monday, 13 May 2019
Room 511BCEF  07:00 - 08:00 Moderators:  Qin Qin, Robert Witte

Skill Level: Basic to Advanced

Session Number: S-M-07

The findings of gadolinium deposition in the brain of patients after previous injection of gadolinium-based contrast agents (GBCA) have resulted in a growing interest in alternative techniques. This course deals with four MRI methods that potentially could replace contrast enhanced MRI: arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) imaging, diffusion MRI, and synthetic MRI.

Target Audience
Trainees, radiologists, physicists, and basic scientists.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the techniques and clinical use of ASL, CEST, diffusion MRI and synthetic MRI; and
- Describe how and when these methods potentially can replace GBCA administration.


  ASL: Technique
Matthias J.P. van Osch
In this presentation, arterial spin labeling MRI is explained as an alternative for acquiring perfusion and 4D angiography images. Moreover, the main advantages and disadvantages will be discussed as well as applications shown.

  Clinical Applications of ASL in the Brain
Marion Smits
Arterial Spin Labeling (ASL) is a non-invasive MRI technique to measure cerebral blood flow (CBF) and other perfusion related parameters such as arterial transit time (ATT). At present, main areas of interest clinically are cerebrovascular disease, dementia and neuro-oncology [1]. 

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