27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Preclinical MRI: Methods & Applications: Contrasts & Probes

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Preclinical MRI: Methods & Applications: Contrasts & Probes
Sunrise Session

ORGANIZERS: Ed Wu, Elena Vinogradov, Lucio Frydman, Damian Tyler, Elena Kaye

Tuesday, 14 May 2019
Room 513A-C  07:00 - 08:00 Moderators:  Noam Shemesh, Elena Vinogradov

Skill Level: Intermediate

Session Number: S-TU-03

Studies of animal models of human pathologies are critical for bridging research "from bench to bedside." Such studies are also essential for understanding the basic biological process and functions in humans. This course will first review the basic physical and biological aspects of in vivo animal MRI, then state-of-art neuroimaging, endogenous and exogenous contrasts, molecular and cellular imaging, and finally other animal imaging modalities including MR-PET and magnetic particle imaging (MPI).

Target Audience
Physicians, imaging scientists/engineers, medical physicists, technologists and other professionals with need for preclinical MR techniques to address transnational, clinical, and basic sciences questions.

Educational Objectives
As a result of attending this course, participants should be able to:
- Apply new MRI hardware and software to better assess small animal models of disease;
- Identify the strengths and limitations of preclinical MRI studies using specific MRI technologies, including MR-PET and MPI; and
- Design basic preclincial MRI experiments, including analyses and validation.


  Exogenous & Endogenous Contrasts
Kannie WY Chan
Imaging proton exchange generates contrast for many biomedical applications. Chemical Exchange Saturation Transfer (CEST) MRI is one of those contrast mechanisms that enables us to sensitively reveal unique molecular information in vivo. This talk will discuss the recent developments in CEST contrast characterizations and its applications. It will be divided into two parts, first part is the endogenous and exogenous molecules that can be detected via CEST, and second part is the preclinical CEST applications in diagnosis and therapy.

  Molecular & Cellular Probes
Video Permission Withheld
Peter Caravan
Here we will present an overview of the different types of exogenous molecular probes (targeted, activatable, CEST, relaxation agents, direct detection, hyperpolarized) using examples from the recent literature to highlight the differences and strengths of each approach.

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