27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Multinuclear Imaging & Spectroscopy: Hyperpolarized 13C Use in Clinical Research & Trials

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Multinuclear Imaging & Spectroscopy: Hyperpolarized 13C Use in Clinical Research & Trials
Sunrise Session

ORGANIZERS: Yi-Fen Yen, Malgorzata Marjanska, Catherine Hines

 
Tuesday, 14 May 2019
Room 512A-H  07:00 - 08:00 Moderators:  Albert Chen, Kim Connelly

Skill Level: Basic to Intermediate

Session Number: S-TU-05

Overview
This is the second course of a four-part sunrise educational series on multi-nuclear imaging and spectroscopy. This course will discuss the current progress of hyperpolarized 13C imaging in clinical research and trials, beginning with technical implementation and demonstrating how trials and clinical studies are currently being performed for oncology and cardiovascular efforts.

Target Audience
MR scientists, MR technologists, clinicians, and scientists interested in performing hyperpolarized 13C studies clinically.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the current progress of hyperpolarized 13C imaging in clinical research for cardiac and cancer applications; and
- Identify the requirements of implementing this technique clinically.
 

 

 
07:00
 
  Clinical Polarizer, Sterilization & Clinical Coils
Daniel Vigneron
 
07:20
 
  Applications in Clinical Cancer Research
Ferdia Gallagher
Hyperpolarized carbon-13 MRI is a new method for imaging tissue metabolism. [1-13C]Pyruvate is the leading probe used with the technique and is converted into lactate under the action of lactate dehydrogenase (LDH). Hyperpolarized carbon imaging has recently been translated into humans and there are a number of sites now undertaking clinical studies. Potential applications may be found in oncology, cardiology and neurology; for example, it has the potential to aid diagnosis, identify disease heterogeneity, predict disease outcome, help target biopsies and determine treatment response non-invasively.

 
07:40
 
  Applications in Clinical Cardiovascular Research
Damian Tyler
This talk will provide an overview of the current status of clinical cardiac hyperpolarized 13C imaging studies and ideas for potential future directions.

 
08:00
 
  Adjournment
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