27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Imaging Without Gadolinium: CEST

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Imaging Without Gadolinium: CEST
Sunrise Session

ORGANIZERS: Pia Maly Sundgren, Elna-Marie Larsson, Robert Witte

Tuesday, 14 May 2019
Room 511BCEF  07:00 - 08:00 Moderators:  Xiang Xu, Robert Witte

Skill Level: Basic to Advanced

Session Number: S-TU-07

The findings of gadolinium deposition in the brain of patients after previous injection of gadolinium-based contrast agents (GBCA) have resulted in a growing interest in alternative techniques. This course deals with four MRI methods that potentially could replace contrast enhanced MRI: arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) imaging, diffusion MRI, and synthetic MRI.

Target Audience
Trainees, radiologists, physicists, and basic scientists.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the techniques and clinical use of ASL, CEST, diffusion MRI and synthetic MRI; and
- Describe how and when these methods potentially can replace GBCA administration.


  CEST Technique
Linda Knutsson
This educational presentation will give a description of the technical aspects of Chemical Exchange Saturation Transfer (CEST) MRI. 

  Clinical Application of CEST
Daniel Paech
Chemical exchange saturation transfer (CEST) MRI is an increasingly applied non-invasive imaging technique with a fast growing body of evidence regarding its diagnostic value, especially in neuroradiology. This class will discuss principle applications of both endogenous and exogenous CEST methods at clinical and ultra-high static field strengths. This will include applications for initial diagnosis and disease characterization (e.g. stroke, cancer, neurodegenerative diseases), outcome prediction, and early therapy response monitoring. Furthermore, an overview of applications in organs systems outside the central nervous system will be given. Difficulties regarding the clinical translation of CEST MRI will be discussed.

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