27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Preclinical MRI: Methods & Applications: Other Animal Imaging Modalities

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Preclinical MRI: Methods & Applications: Other Animal Imaging Modalities
Sunrise Session

ORGANIZERS: Ed Wu, Elena Vinogradov, Lucio Frydman, Damian Tyler, Elena Kaye

Wednesday, 15 May 2019
Room 513A-C  07:00 - 08:00 Moderators:  Xiaoping Hu, Alex T. L. Leong

Skill Level: Intermediate

Session Number: S-W-03

Studies of animal models of human pathologies are critical for bridging research "from bench to bedside." Such studies are also essential for understanding the basic biological process and functions in humans. This course will first review the basic physical and biological aspects of in vivo animal MRI, then state-of-art neuroimaging, endogenous and exogenous contrasts, molecular and cellular imaging, and finally other animal imaging modalities including MR-PET and magnetic particle imaging (MPI).

Target Audience
Physicians, imaging scientists/engineers, medical physicists, technologists and other professionals with need for preclinical MR techniques to address transnational, clinical, and basic sciences questions.

Educational Objectives
As a result of attending this course, participants should be able to:
- Apply new MRI hardware and software to better assess small animal models of disease;
- Identify the strengths and limitations of preclinical MRI studies using specific MRI technologies, including MR-PET and MPI; and
- Design basic preclincial MRI experiments, including analyses and validation.


  Preclinical MR-PET
Stephen Sawiak
MR-PET offers new horizons for quantitative, specific assessment in animal models. Here the basic principles are described along with advantages and pitfalls.

  Introduction to Magnetic Particle Imaging (MPI)
Magnetic Particle Imaging (MPI) is an emerging molecular imaging technique that directly detects superparamagnetic nanoparticle tracers. First introduced in 2005 by Gleich and Weizenecker, MPI sensitively detects nanoparticle tracers using their magnetic nonlinearity with magnetic gradient fields.  The images produced are specific to the tracer, without any confounding signal from tissue. The resulting images resemble those taken with nuclear medicine and are often paired with an anatomic modality such as CT or MRI. Similar to MRI, MPI does not use ionizing radiation and the signal does not change with tissue depth.

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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.