27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Microstructure for Clinical Use

Back to Program-at-a-Glance

Microstructure for Clinical Use
Sunrise Session

ORGANIZERS: Masaaki Hori, Dmitry Novikov, Ivana Drobnjak

Wednesday, 15 May 2019
Room 510A-D  07:00 - 08:00 Moderators:  Masaaki Hori, Timothy Shepherd

Skill Level: Intermediate

Session Number: S-W-04

This course will present recent studies demonstrating the utility of the diffusion microstructural imaging for clinical use.

Target Audience
Scientists and clinicians interested in applications of microstructure imaging for clinical use.

Educational Objectives
As a result of attending this course, participants should be able to:
-Describe the types of tissue microstructure changes in in-vivo tissues;
-List the types of tissue changes that may be detected by diffusion microstructural imaging; and
-Identify the correlation between diffusion metrics and clinical outcome.


  Microstructure Imaging for Clinical Use
Kouhei Kamiya
Recent applications of microstructure imaging in clinical studies are introduced. The reported results show microstructure imaging holds promise to provide clinically valuable information, though further validation and optimization are necessary to be really used in the clinics.

  Basic Overview of Microstructure Models
Jennifer Campbell, G. Bruce Pike
Diffusion MRI has the ability to probe tissue microstructure in detail, due to the effect microstructure has on the motion of water molecules moving due to random thermal motion. After acquiring a series of diffusion weighted images (DWIs), there are numerous post-processing approaches that generate quantitative maps with varying degrees of sensitivity and specificity to microstructural properties. This lecture focuses on microstructural models, i.e., approaches that employ an a priori description of the tissue characterized by specific quantitative parameters that will be estimated from the diffusion MRI signal. It reviews the standard model of diffusion MRI microstructure and its variants, with emphasis on its limitations and recent progress toward reducing these limitations. Understanding these limitations is important for prudent interpretation of results in a clinical context.

Back to Program-at-a-Glance   |   Back to Top
The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.