27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Sunrise Session
Imaging Without Gadolinium: Diffusion MRI

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Imaging Without Gadolinium: Diffusion MRI
Sunrise Session

ORGANIZERS: Pia Maly Sundgren, Elna-Marie Larsson, Robert Witte

Wednesday, 15 May 2019
Room 511BCEF  07:00 - 08:00 Moderators:  Manisha Aggarwal, Robert Witte

Skill Level: Basic to Advanced

Session Number: S-W-07

The findings of gadolinium deposition in the brain of patients after previous injection of gadolinium-based contrast agents (GBCA) have resulted in a growing interest in alternative techniques. This course deals with four MRI methods that potentially could replace contrast enhanced MRI: arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) imaging, diffusion MRI, and synthetic MRI.

Target Audience
Trainees, radiologists, physicists, and basic scientists.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the techniques and clinical use of ASL, CEST, diffusion MRI and synthetic MRI; and
- Describe how and when these methods potentially can replace GBCA administration.


  Diffusion Techniques
Markus Nilsson
This lecture will cover the basics of diffusion MRI acquisitions, raise awareness of how imaging protocol parameters can affect the study outcome, provide an overview of recently developed diffusion techniques, and explain the relationship between representations, biophysical models, and imaging biomarkers.

Clinical Applications of Brain Diffusion
Susie Huang
Diffusion MRI is a key contrast mechanism that is used primarily in clinical neuroimaging for identifying acute ischemia.  However, many other pathological processes can also demonstrate restricted diffusion, including viscous material/pus within abscesses, cytotoxic edema in infection and neuro-inflammation, and highly cellular tumors.  This overview of clinical applications of diffusion MRI in the brain will illustrate the utility of diffusion MRI as a contrast mechanism through clinical case examples and demonstrate how diffusion may be used in place of gadolinium-based contrast agents to provide a specific diagnosis.

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