27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Combined Educational & Scientific Session
Mapping the Complementary Roles of Myelin & Microstructure in White Matter

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Mapping the Complementary Roles of Myelin & Microstructure in White Matter
Combined Educational & Scientific Session

ORGANIZERS: Noam Shemesh, Alexander Leemans, Jongho Lee

 
Thursday, 16 May 2019
Room 516C-E  13:45 - 15:45 Moderators:  Nikola Stikov, Adrienne Dula

Skill Level: Intermediate

Session Number: TH-05

Overview
White matter of the brain has a unique microstructural composition that divides white matter into multiple compartments. This session will introduce a few quantitative microstructural imaging methods that measure the white matter compartments (e.g. myelin and axon).

Target Audience
Physicians and scientists wanting to explore methodologies for quantitative microstructural imaging techniques for white matter; physicians and scientists engaged in advanced white matter imaging for scientific and clinical research.

Educational Objectives
As a result of attending this course, participants should be able to:
- Describe the microstructural composition of white matter;
- Summarize various white matter microstructural imaging methods with their imaging targets; and
- Explain the technical limitations of the methods.

 

 
13:45
 
  
 
Diffusion Goes Multi-Modal: Myelin Mapping
Mark Does
14:15
 
  
 
g-Ratio Mapping: Challenges & Validation
Jennifer Campbell, Ilana Leppert, G. Bruce Pike
The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon. In healthy neural tissue, it is optimized for speed of signal conduction, cellular energetics, and spatial constraints. The g-ratio is a fundamental contributor to functionally relevant neuronal properties such as conduction velocity. g-Ratio imaging has the potential to allow us to investigate in vivo g-ratio changes in health and disease. This lecture details the methodology for imaging the g-ratio with MRI, describes the known challenges in doing so, presents validation work to date, and discusses challenges in validating the technique.

 
14:45-15:33   T.B.A.
16:03
 
  
 
Adjournment
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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.