27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Combined Educational & Scientific Session
MRS of Lipids & Fatty Acids

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MRS of Lipids & Fatty Acids
Combined Educational & Scientific Session

ORGANIZERS: Catherine Hines, Ronald Ouwerkerk

Tuesday, 14 May 2019
Room 512A-H  08:15 - 10:15 Moderators:  Naranamangalam Jagannathan, Kyu-Ho Song

Skill Level: Basic to Intermediate

Session Number: TU-02

This course will provide insight in the role of lipids in cancer metabolism and explain how MR-visible lipids can provide insight in the microenvironment of tumor cells and how this can be used for cancer diagnosis and the monitoring of treatment response in animal models and in humans. The second lecture will focus on 1H and 13C MRS methods to quantify lipid content and characterize lipid compositions and how this can help understand fatty acid metabolism and its role in a variety of diseases.

Target Audience
MR scientists, MR technologists, clinicians, and scientists interested in performing MR spectroscopy studies to investigate metabolic processes in oncology and other diseases or developing related methodologies.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify what lipids are visible with MR;
- Explain how lipid metabolism is linked (micro)environmental factors such as inflammation, acidity, and oxygen in tumors;
- Describe changes that may occur in the MR visible lipids, the development of cancer, in apoptosis, and in successful therapy;
- Name a number of 13C and 1H-MRS techniques to quantify and characterize lipids in-vivo;
- Recognize lipid metabolism and its link to metabolic switches, redox state; and
- Describe what MRS observation of lipid content or composition can reveal about metabolic state and metabolic diseases.


MRS of Lipids & Fatty Acids: Metabolism, Composition & Quantification
Corin Miller
Lipids are a large class of biomolecules naturally occurring in different forms throughout the body.  As many lipid species tend to exist in high concentrations, they are an abundant source of MR-observable nuclei.  This presentation will review the measurements of lipids that have been made successfully with MRS-based approaches and highlight the important findings from MRS studies of lipids.   Specifically, focus will be on the following areas: (1) Introduction to characteristics of lipids, (2) Detection and quantification of lipid levels with 1H MRS, (3) Assessment of lipid composition with 1H MRS and 13C MRS too, (4) Measurement of the kinetics of lipid metabolism with 13C MRS.

MRS of Lipids & Fatty Acids: Relevance in Cancer
E. Jim Delikatny
09:35-09:55   T.B.A.
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