27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Combined Educational & Scientific Session
Cell Tracking & Molecular Imaging Using Exogenous Agents

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Cell Tracking & Molecular Imaging Using Exogenous Agents
Combined Educational & Scientific Session

ORGANIZERS: Ronald Ouwerkerk, Kannie WY Chan, Yi-Fen Yen

Wednesday, 15 May 2019
Room 516C-E  13:30 - 15:30 Moderators:  Guanshu Liu, Nirbhay Yadav

Skill Level: Basic to Intermediate

Session Number: W-07

An overview of methods and applications of MR based cell tracking methods using contrast agents or bioorganic contrast enhancement. Mechanisms based on gadolinium, super-paramagnetic ion, fluorine, and methods based on chemical exchange saturation transfer are discussed. The current and future clinical applications are also discussed.

Target Audience

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify methods available to probe cell distribution, cell survival, cell function, cell differentiation, and cellular enzymatic activity; and
- List which probes are suitable for humans use and which probes have made it into clinical trials.


Clinical Applications of MR Cell Tracking
Jeff Bulte
MRI is expected to play a key role in evaluating the outcome of clinical trials based on stem and immune cell therapy. In order to facilitate and implement the translation of these therapies into the clinic, it will be necessary to monitor the immediate cellular engraftment, subsequent biodistribution and migration, and cell survival and differentiation non-invasively over time. 

Methods for Cell Tracking
Erik Shapiro
MRI has proven to be a powerful imaging modality for non-invasive, whole body imaging, with meaningful image resolution for studying cellular dynamics. MRI contrast is generated by capitalizing on differences in water molecule microenvironment, including diffusion rate and direction, magnetic field differences, and water content. In order to use MRI to distinguish a unique population of cells from other cells in the body, such as a cell transplant, or the infiltration of immune cells to a disease, one of these properties needs to be altered, or a tracer needs to be introduced. This will generate contrast or signal from these cells.

14:30 - 16:00   T.B.A.
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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.