27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Weekend Educational Session
Diffusion & Microstructure: Lectures & Exercises

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Diffusion & Microstructure: Lectures
Weekend Course

ORGANIZERS: Dmitry Novikov, Ivana Drobnjak

Saturday, 11 May 2019
  08:00 - 13:30 Moderators:  Ivana Drobnjak, Dmitry Novikov

Skill Level: Basic to Intermediate

Session Number: WE-05A

This course will discuss foundations of diffusion physics and basic experimental design, followed by the overview of microstructure models and advanced experimental and parameter estimation techniques.

Target Audience
Everyone who wants to understand the biophysical origins of diffusion signal and design experiments. Developed in sync with the subsequent problem-solving session in the afternoon.

Educational Objectives
As a result of attending this course, participants should be able to:
- Explain the physics of diffusion;
- Describe basic diffusion MRI sequences;
- Compare and contrast biophysical models and representations;
- Describe microstructural parameter estimation methods; and
- Identify imaging artifacts and the associated biases in the measured parameters.


  Diffusion Fundamentals
Marco Palombo
  Experimental Design & Acquisition for Diffusion
Jana Hutter
Single-shot Pulsed Gradient Spin Echo echo planar imaging remains the most commonly used sequence for diffusion MRI. However, recent years have seen numerous extensions. This lecture will introduce both the basic modular elements and more experimental novel approaches including modified diffusion preparations, read-out accelerations and combinations with additional contrasts such as relaxometry. 

  Image Artifacts & Processing Pipelines
Jelle Veraart
  Break & Meet the Teachers
  Overview of Microstructure Models
Sune Jespersen
  Overview of Microstructure Models
  Lunch & Meet the Teachers
Diffusion & Microstructure: Exercises
Weekend Course

ORGANIZERS: Dmitry Novikov, Ivana Drobnjak

Saturday, 11 May 2019
  13:30 - 15:30 Moderators:  Dmitry Novikov, Noam Shemesh

Skill Level: Basic to Advanced

Session Number: WE-05B

It is only through the suffering that one reaches enlightenment. Slides and passionate talks give you only a glimpse of knowledge, but the real insight is earned when you have to face a problem one-on-one, sometimes just with paper and pencil. This is your chance to stare into the abyss. 

A set of problems will be given to students based on the morning lecture course, co-developed by the morning and afternoon lecturers. Students will solve problems by themselves or, if they prefer, in small ad-hoc groups. About 10 min should be given for the students to try each problem, immediately followed by an in-depth discussion on a big board, with pitfalls identified and applications discussed. Then on to the next problem. Isn't this the most awesome way to spend your afternoon?

Target Audience
The not-for-the-faint-of-heart subset of the morning session attendees.

Educational Objectives
As a result of attending this course, participants should be able to:
- Develop practical skills and valuable intuition in making simple estimates for diffusion and microstructure parameters;
- Recognize the role of diffusion time and of diffusion wave vector in probing tissue length scales;
- Identify the biases originating from improper experimental design and imaging artifacts, and develop the ways to correct for them; and
- Explain how messy the scientific process really is, and how different it is from the polished outline of results in papers and talks.


  Problems: Diffusion Basics
Chantal Tax
  Problems: Microstructure Models
Valerij Kiselev
  Break & Meet the Teachers
  Problems: Experimental Design & Acquisition
Matthias Weigel
  Problems: Image Artifacts & Processing Pipelines
Rita Nunes
  Adjournment & Meet the Teachers
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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.