27th ISMRM Annual Meeting • 11-16 May 2019 • Montréal, QC, Canada

Weekend Educational Session
Neurofluids & Brain Lymphatics: From Bench to MRI

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Neurofluids & Brain Lymphatics: From Bench to MRI
Weekend Course

ORGANIZERS: Nivedita Agarwal, Kei Yamada

Sunday, 12 May 2019
  08:00 - 11:50 Moderators:  Nivedita Agarwal

Skill Level: Basic to Advanced

Session Number: WE-20

This course aims to provide an overview of basic CNS fluid physiology and identify MRI tools to image fluids and brain vessels. International experts will outline the current understanding of CNS fluid dynamics and CSF circulation. A mathematical modeling approach to understand physiology will be discussed, useful to infer possible pathological conditions due to pressure/volume changes in the brain and the spine. The recent discovery of the glymphatic system and the possibility of visualizing brain lymphatic system will be put into context. Lastly, novel MR techniques in pathology will be discussed. 

Target Audience
Clinicians, neuroscientists, researchers, mathematicians, and computer scientists.

Educational Objectives
As a result of attending this course, participants should be able to:
- Identify evolving concepts around basic CNS fluid physiology;
- Recognize brain lymphatic channels and glymphatic flow;
- Interpret idiopathic diseases in the light of neurofluid dynamic changes; and
- Apply knowledge gained to develop novel MR methods.



  Basic CNS Fluid Physiology
Andreas Linninger
  Interacting Fluid Compartments of the Central Nervous System: A Holistic Mathematical Modelling Approach
Eleuterio Toro
  Role of Neurofluids in Neurological Diseases
Maria Marcella Laganà
  MR Imaging of CSF Spaces
Shigeki Yamada, Masatsune Ishikawa, Makoto Yamaguchi, Kazuo Yamamoto

We have studied how to visualize “neurofluids” three-dimensionally by using transparency and perspective technologies with shading and texture mapping from volumetric magnetic resonance imaging. The mean volume of the intracranial cerebrospinal fluid (CSF) in healthy individuals aged ≥70 years was estimated at more than 300 mL. CSF movement with cardiac pulsation was reduced with increasing age, although the dynamics of neurofluids has not been elucidated. By developing fluid dynamics-related technology, the 3D movement of CSF can be measured quantitatively. CSF dynamic theory has been renewed; the CSF does not exhibit unidirectional bulk flow and moves in a pulsatile fashion.

  Break & Meet the Teachers
  Mechanisms of Brain Drain
Roxane Carare
  Mechanisms of Brain Drain: Glymphatics
  From Magnetic Resonance to Mathematical Models for Flow Dynamics
Christian Contarino
  Imaging Brain Lymphatics
Toshiaki Taoka
  Lunch & Meet the Teachers
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The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.