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Assessment of Cerebello-Thalamo-Cortical (CTC) Fiber Pathways in Post-Surgical Medulloblastoma Patients Using a CTC Template
Qing Ji1, Matthew Scoggins1, Angela Edwards1, John O. Glass1, Tara Brinkman2,3, Zoltan Patay1, and Wilburn E. Reddick1
1Diagnostic Imaging, St.Jude Children's Research Hospital, Memphis, TN, United States, 2Psychology, St.Jude Children's Research Hospital, Memphis, TN, United States, 3Epidemiology and Cancer Control, St.Jude Children's Research Hospital, Memphis, TN, United States
Based on similarities of streamlines in the human CTC pathway, this study proposed a method of “implementing” a CTC template obtained from multiple healthy controls to the individual patient instead of directly performing DTI fiber tracking.   
Figure 1 Illustration of the process for constructing CTC fiber template.
Figure 5 The CTC template was aligned to 12 subjects. The FA distribution along CTC tracts of those 12 subjects were shown. The subject 1 was a normal control and subjects 2 to subject 12 were postoperative medulloblastoma patients. Subject 2 4 6 8 and 11 had bilateral native tractable CTCs. Subject 3, 5, 7, and 9 have unilateral left native tractable CTCs. The bilateral CTCs for subject 10 and 12 were natively intractable.