Zixuan Lin1, Dengrong Jiang1, Zachary Baker1, Dapeng Liu1, Yang Li1, Xirui Hou1, Jay J. Pillai1, Qin Qin1, Yulin Ge2, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, New York University Langone Medical Center, New York, NY, United States
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Radiology, New York University Langone Medical Center, New York, NY, United States
In this
study, we harmonized WEPCAST MRI for BBB permeability assessment across two major vendors and examined the test-retest reproducibility of the technique. The
results showed that WEPCAST MRI can give a reliable assessment of BBB
permeability with an excellent reproducibility.
Figure 2. Comparison
of WEPCAST results from two scanners. (a) Representative WEPCAST control and
difference images for one participant from two scanners. (b) WEPCAST signal
profile of SSS from two scanners and scatter plot of water extraction fraction
measured from two scanners. (c) Bland-Altman plots comparing PS measurements on
two scanners. The solid line indicates the average difference between two
scanner and the dashed line indicate the 95% confidence interval.
Figure 3. Test-retest
reproducibility of WEPCAST MRI, including intra-session CoV, inter-session CoV
and inter-scanner CoV of PS measurements.