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Evaluation of longitudinal changes in white matter structural integrity and grey matter volume in Parkinson’s disease
Maurizio Bergamino1, Elizabeth Keeling1,2, Ryan R Walsh3, and Ashley M Stokes1
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Neuroscience Department, Arizona State University, Phoenix, AZ, United States, 3The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States
Advanced DTI metrics (gFA and FW index) and GM volume may provide insight into longitudinal progression in PD, relative to controls. Longitudinal decreases in gFA and GM volume and increases in FW index in PD were observed.
F-stats from 2x2 ANOVA for gFA and FW metrics. In panel (a) the significant clusters for the main effect of TP are shown (for only gFA). Panels (b) and (c) show the significant clusters for group×TP interaction (FW and gFA, respectively). Table in panel (d) shows the summary of the results.
F-stats from 2x2 ANOVA for VBM analysis. In panel (a) the significant clusters for the main effect of TP are shown, while panel (b) shows the significant clusters for group×TP interaction. Table in panel (c) shows the summary of the results.