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Presurgical planning of MRgFUS for Essential Tremor (ET) with protocol for high quality DTI
Amritha Nayak1,2, Angela Bissoli3, Okan M Irfanoglu2, Guiseppe Ricciardi3, Elisa Ciceri3, and Carlo Pierpaoli Pierpaoli2
1Henry Jackson Foundation for advancement in Military Medicine Inc, Rockville, MD, United States, 2National Insitutes of Health, Bethesda, MD, United States, 3Azienda Ospedaliera Universitaria Integrata, Verona, Italy
The role of high quality DTI is clearly highlighted in this preliminary evaluation, to more accurately identify the initial target for sonication in MRgFUS presurgical planning.
Figure2: Top row: coronal view of the acute postsurgical T2WI from four patients where final target has been identified (blue dot), based on the criteria described in figure1. Bottom row: coronal view of the high quality presurgical DTI and the corresponding location of the final target, for each patient.
Figure3: Left column: In patient 3, the location of the first target point of sonification on postsurgical T2WI and its corresponding location on the high quality DTI. The sub threshold initial sonication at this site resulted in patient experiencing slight paresthesia. Right column: The final target location selected for surgery based on the positive functional feedback received from the patient and its corresponding location on the presurgical high quality DTI.