Scott Kolbe1, Meaghan Clough1, Frederique Boonstra1, Myrte Strik2, Anneke van der Walt1, Helmut Butzkueven1, Owen White1, Joanne Fielding1, and Meng Law1
1Monash University, Prahran, Australia, 2University of Melbourne, Parkville, Australia
1Monash University, Prahran, Australia, 2University of Melbourne, Parkville, Australia
Axonal fibre density measured from clinically acquired diffusion weighted imaging data is seven times more sensitive to longitudinal change compared to brain atrophy.
Figure 1. Top row: Template fibre map showing regions included in analysis. Bottom row: Regions of significant correlation (FWE-corrected p<0.05) between fibre density and brain parenchymal fraction at baseline.
Figure 2. Regions showing significant longitudinal decline in fibre density over time in patients (FWE-corrected p<0.05).
