Maurizio Bergamino1, Ashley Nespodzany1, Leslie C Baxter1,2, Anna Burke3, Richard Caselli2, Marwan N Sabbagh4, Ryan R Walsh5, and Ashley M Stokes1
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Mayo Clinic Arizona, Phoenix, AZ, United States, 3Department of Neuropsychiatry, Barrow Neurological Institute, Phoenix, AZ, United States, 4Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, 5The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Mayo Clinic Arizona, Phoenix, AZ, United States, 3Department of Neuropsychiatry, Barrow Neurological Institute, Phoenix, AZ, United States, 4Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, 5The Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, United States
IVIM-DWI was used to investigate early
AD-related microstructural and functional changes. Significant differences were
observed using IVIM biomarkers between healthy controls, MCI, and AD groups,
while VBM showed differences only in later AD stages.
Voxel-based analysis
for the F-statistics across groups for all analysis methods. VBM results are
also shown uncorrected for family-wise error (FWE) in panel (a). For all other
panels, we report clusters at a significance threshold of p-value < 0.05 corrected for FWE.
Voxel-based
correlations between MoCA/Clock Draw/FAST and VBM/ADC/IVIM metrics. The plots,
with the relative mean of R2, represent the correlations of the
average values inside the significant clusters.
