Chun-Xia Li1, Yumei Yan1, Longchuan Li2, Todd Preuss3, James G Herndon3, Xiaoping Hu4, and Xiaodong Zhang1,3
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Pediatric, Emory University School of Medicine, Atlanta, GA, United States, 3Division of Neuroscience and Neurological diseases, Emory University, Atlanta, GA, United States, 4Department of bioengineering, University of California, Riverside, Riverside, CA, United States
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Pediatric, Emory University School of Medicine, Atlanta, GA, United States, 3Division of Neuroscience and Neurological diseases, Emory University, Atlanta, GA, United States, 4Department of bioengineering, University of California, Riverside, Riverside, CA, United States
Mean
diffusivity (MD), axial diffusivity (AD or λll), radial diffusivity
(RD or λτ) and fractional anisotropy (FA) showed mild and
proportional changes from youth to elder adulthood in elder chimpanzees, significant
increase of MD and RD were seen as well. The changes are much milder than that
seen in monkey and human brain.
Fig 2
Demonstration of progressive changes of DTI indices (FA, MD, AD, RD) in
chimpanzee optic nerves.
Fig 3.
progressive evolution of DTI indices of the optic nerve in chimpanzees
with the ages of 13-20(n=13), 22-38(n=10), and 40-56 (n=7) years old.
*, p<0.07;
#, p<0.1,
compared
22-38y
group by using one-way ANOVA. Error bar: standard deviation
