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AMURA with standard single-shell acquisition can detect changes beyond the Diffusion Tensor: a migraine clinical study
Álvaro Planchuelo-Gómez1, Rodrigo de Luis-García1, Antonio Tristán-Vega1, David García-Azorín2, Ángel Luis Guerrero2, and Santiago Aja-Fernández1
1Imaging Processing Laboratory, Universidad de Valladolid, Valladolid, Spain, 2Headache Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
Advanced diffusion measures calculated with AMURA detect changes in migraine patients compared to controls that are not detected by traditional DTI measures. AMURA can give complementary information to DTI-based studies even with low b­-values.
Figure 4. Summary of the results obtained in the diverse analyses. Significant differences between episodic migraine (EM) and controls were found only with the AMURA return-to-origin probability (RTOP), detecting white matter alterations non-measurable with Diffusion Tensor Imaging (DTI). Differences between chronic migraine (CM) and EM were found with return-to-plane probability (RTPP) obtained with AMURA and axial diffusivity (AD) from DTI. No differences were found between CM and controls.
Figure 5. Visual comparison of Diffusion Tensor Imaging (DTI) and Apparent Measures Using Reduced Acquisitions (AMURA). The first row contains the DTI measures, from left to right: axial (AD), mean (MD) and radial diffusivity (RD). The second row contains AMURA metrics, from left to right: return-to-plane (RTPP), return-to-origin (RTOP) and return-to-axis probability (RTAP).