A longitudinal study on heterogeneity of diffusional parameters of spontaneously-hypertensive rats.
Jung-Sen Hsiao1, Hung-Yu Fu1, Pei-Lun Yu1, Sheng-Min Huang1, Kung-Chu Ho2, and Fu-Nien Wang1
1Biomedical Engineering and Envionmental Sciences, National Tsing-Hua University, Hsinchu City, Taiwan, 2Chang-Gung Memorial Hospital, Taoyuan City, Taiwan
Six spontaneously-hypertensive rats in different ages were scanned on a 7T small animal MR scanner to investigate the diffusional heterogeneity in gray matter by DKI. The diffusional heterogeneity is anticipated as a potential image-based biomarker for evaluating tissue integrity.
Table 1. Tissue characterization ability between mean value and CV by DKI. The number represents the total numbers in eight maps calculated from diffusivities and kurtosis, derived from DKI.
Figure 2. Diffusional heterogeneities of DKI were tested for the tissue characterization.