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Brain microstructural alterations of left precuneus mediate the association between KIBRA rs17070145 and working memory in healthy adults.
Junxia Wang1, Sichu Wu2, Jilei Zhang3, and Bing Zhang2
1Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China, 2Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 3Clinical Science, Philips Healthcare, Shanghai, Shanghai, China
KIBRA C-allele carriers had increased AD, RD, MD and decreased FA, MK, RK, ALFF compared with KIBRA TT homozygotes. The MK, RK of the left precuneus mediated the association between the KIBRA polymorphism and the working memory performance. 
Figure 3 Mediation analysis for the associations among KIBRA, MK, RK, ALFF in the left precuneus and working memory.
Figure 1 Comparison of diffusion and kurtosis metrics between KIBRA C and TT groups.