Intravoxel incoherent motion and diffusion kurtosis imaging in the assessment of pathological grades of clear cell renal cell carcinoma
Qing Xu1, Weiqiang Dou2, and Jing Ye1
1Department of Radiology, Clinical Medical School of Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, 457, China, 2GE Healthcare, MR Research China, Beijing, China
IVIM-related parameters (ADC, apparent diffusion coefficient;
D, true diffusivity) and DKI-related parameters (MD, mean diffusivity; MK, mean
kurtosis) were able to significantly distinguish between low- and high-grade
clear cell renal cell carcinoma.
A 65-year-old woman with pathologically confirmed
epithelioid angiomyolipoma in the left kidney. The lesion showed low signal
intensity (SI) on T2-weighted image (a). (b-g) Corresponding parametric
maps(ADC, D, D*,f, MD, MK). Tumor values (white arrow) were 0.51×10−3 mm2/s,
1.04×10−3 mm2/s, 57.8×10−3 mm2/s, 0.24, 1.67, 0.77,
respectively. (h) pathological analysis displayed changes indicating ccRCC
(Fuhrman II) (hematoxylin and eosin, ×200).
A 66-year-old man with pathologically confirmed clear
cell renal cell carcinoma in the right kidney. The lesion showed very low
signal intensity (SI) on T2-weighted image (a). (b-g) Corresponding parametric
maps (ADC, D, D*,f, MD, MK). Tumor values (white arrow) were 0.32×10−3 mm2/s,
0.92×10−3 mm2/s, 10.09×10−3 mm2/s, 0.43, 1.05, 1.01,
respectively. (h) pathological analysis confirmed ccRCC (Fuhrman IV) (hematoxylin
and eosin, ×200).