Educational Course
The Brain-Gut Axis: Imaging the Superorganism
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Session Topic: Brain-Gut Axis and AI in Neuroimaging
Session Sub-Topic: The Brain-Gut Axis: Imaging the Superorganism
Weekday Course
ORGANIZERS: C. C. Tchoyoson Lim, Nivedita Agarwal
| Thursday Parallel 2 Live Q&A | Thursday, 13 August 2020, 15:50 - 16:35 UTC | Moderators: Zhongming Liu |
Skill Level: Basic to Advanced
Session Number: Tu-03
Overview
There is growing scientific evidence that the enteric nervous system (gut) and the central nervous system (brain) communicate bidirectionally in a complex manner to monitor and integrate gastrointestinal functions as well as to shape cognitive and emotional functions. Preliminary animal studies provide evidence that nutrition can affect intestinal microbiome and brain structure/function. We will discuss the basic anatomy of the microbiome brain-gut axis, its physiology, and how alterations of this axis can cause neurological disorders.
Target Audience
This session is open to all scientists, neuro and body, clinicians, and physicists who can benefit from understanding the still elusive brain-gut axis.
Educational Objectives
As a result of attending this course, participants should be able to:
- Recognize the basic anatomy of the brain-gut axis, and its bidirectional communication through nervous and hormonal systems;
- Explain how alterations of this axis (and dysbiosis) can cause brain disorders;
- Review preclinical animal studies on the effect of nutrition and microbiota; and
- Summarize the small yet growing body of evidence from MR imaging regarding changes in brain connectivity.
| Neuroimaging the Gut-Brain Axis: Influence of the Gut Microbiome on Brain Microstructure
John-Paul Yu
With well-established associations between gut microbiome populations, brain structure and function, and neurological disease and neuropsychiatric illness, the concomitant changes in neural tissue microstructure occurring parallel to these changes in the composition of the gut microbiome remain poorly characterized. We present new evidence for the neural microstructural correlates underpinning these mechanistic changes, the association between specific gut microbiome populations and brain microstructure, and the role of the human gut microbiome in the microstructural complexity of the developing brain.
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| Neuroimaging of the Brain-Gut Axis
Ling Ling Chan Video Permission Withheld
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