ISMRM20 Weekend: How to Conduct the “Ideal” In Vivo Preclinical MR Experiment

Weekend Educational Session

How to Conduct the “Ideal” In Vivo Preclinical MR Experiment

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Session Topic: How to Conduct the “Ideal” In Vivo Preclinical MR Experiment

Session Sub-Topic: How to Conduct the “Ideal” In Vivo Preclinical MR Experiment

Weekend Course

ORGANIZERS: Arvind Pathak

Sunday Parallel 3 Live Q&A

Sunday, 9 August 2020, 14:30 - 15:00 UTC

Moderators: Harish Poptani & Jürgen Schneider

Skill Level: Basic to Advanced

Session Number: WE-15

Overview
This didactic session will cover the basics of all the considerations that go into making a successful preclinical in vivo experiment.

Target Audience
Anyone interested in preclinical MRI, from beginners to expert users, will benefit from these lectures.

Educational Objectives
As a result of attending this course, participants should be able to:
- Demonstrate the following: handle animals, select anesthetics, and implement physiological control and monitoring;
- Recognize the pros and cons of using clinical vs. preclinical MR hardware for imaging;
- Recognize the pros and cons of clinical vs. preclinical acquisition, reconstruction schemes as well as issues related to technique translation;
- Identify data analysis and software tools for preclinical experimentation;
- Describe multimodality imaging and techniques that complement preclinical MRI; and
- Explain data interpretation and fundamental statistical analyses.

		Considerations When Designing an In Vivo Experiment: Animal Handling, Anesthesia, Physiological Monitoring, Etc. Olli Gröhn Watch the Video stress level of the animals influences most of the study designs where preclinical MRI is utilized. Furthermore, anesthesia has profound effect on fMRI, and extreme care has to be taken while choosing the type of anesthesia and for monitoring the anesthesia level and physiological state of the animal in order to obtain reliable and reproducible results. Protocols for scanning awake animals have been around for two decades but only recently have become more popular due to increased awareness on importance of physiological factors for (f)MRI results.
		Using Clinical vs. Preclinical Hardware Michael McMahon Watch the Video
		Clinical vs. Preclinical Data Acquisition, Reconstruction & Translation Jack Miller Watch the Video Pre-clinical MRI is a powerful and important tool for addressing a variety of basic scientific questions, as well as providing a unique platform for technique development. This course explores its quantitative differences from clinical MR, with a strong emphasis on the statistical analysis of the data it provides, within the context of addressing basic scientific questions.
		Data Analysis & Software Considerations Mark Pagel Watch the Video This didactic presentation will describe aspects of data analysis and software considerations when performing the "ideal" small animal MRI study. Topics include considerations for 1) incorporating image analysis into the experimental design and financial budget before starting the study; 2) data quality for good analyses; 3) registration and segmentation; 4) repeatability, reproducibility, and rigor of data analyses. Each of these topics will be highlighted with a practical example.
		Multimodality Imaging Techniques Complementary to MRI Kristine Glunde Watch the Video