ISMRM21 - Real-Time MRI of Neuromodulation in the Human Brain

Real-Time MRI of Neuromodulation in the Human Brain

Member-Initiated Symposium

Tuesday, 18 May 2021

Concurrent 4

12:00 - 14:00

Moderators: Jia-Hong Gao

Session Number: MIS-05

Parent Session: Real-Time MRI of Neuromodulation in the Human Brain

Session Number:MIS-05

Organizers
Danny JJ Wang

Overview
During recent years, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS), have become an important means to study how complex neural circuits interact in the brain, through stimulation or modulation of neuronal activities, to manipulate human cognition and to treat brain disorders. With the latest technical advances, MRI can now be performed concurrently with these neuromodulation techniques to visualize their effects on the human brain in real time, to understand the neurophysiological mechanism, and to improve their efficacy. This topic is highly relevant to the theme and growing interests of ISMRM for MRI-guided therapy and MRI with implants. In this symposium, Dr. Rosalind Sadleir will first introduce the MR Electrical Impedance Tomography (MREIT) technique that enables the measurement of current density distributions during tDCS in-vivo. Dr. Mayank Jog will then present a novel imaging technique that enables concurrent mapping of the tDCS current-induced magnetic field and neurophysiological changes using MRI. Drs. Yihong Yang and Julian Neumann will then present new findings using concurrent MRI and TMS, as well as concurrent MRI and DBS, respectively. The four speakers are leaders of the field with diverse backgrounds and international representations. Finally, the audience will have opportunities to interact with the speakers through panel discussion.

Target Audience
MRI researchers, neuroscientists, psychiatrists, and neurosurgeons interested in in-vivo imaging of neuromodulation effects on human brain using MRI.

Educational Objectives
As a result of attending this course, participants should be able to:
Upon completion of this course, participants should be able to: - Describe the state of the art and latest developments of concurrent MRI and neuromodulation techniques including tDCS, TMS, and DBS; - Define the biophysical and neurophysiological parameters that can be measured by MRI during neuromodulations; - Recognize the potentials and challenges of in-vivo MRI mapping of neuromodulations; and - Identify the suitable clinical applications and associated barriers needed to be overcome for the translation of MRI mapping of neuromodulations.

			MR Electrical Impedance Tomography (MREIT) of Transcranial Direct Current Stimulation (tDCS) Rosalind Sadleir Arizona State University
			Concurrent Mapping of Electromagnetic Field & Neurophysiological Effects of tDCS Using MRI Mayank Jog University of California, Los Angeles
			Understanding TMS Effects on the Brain: Simultaneous TMS & MRI Yihong Yang National Institute of Drug Abuse (NIDA)
			Functional Network Neuromodulation of the Motor System: MRI-Based Connectivity Analysis Can Reveal Clinical, Behavioral & Neural Consequences of DBS in Parkinson’s Disease Wolf-Julian Neumann Charité - University Medicine Berlin