ISMRM21 - Looking Beyond Axons: Imaging the Immune System in White Matter

Looking Beyond Axons: Imaging the Immune System in White Matter

Member-Initiated Symposium

Wednesday, 19 May 2021

Concurrent 8

16:00 - 18:00

Moderators: Els Fieremans & Shannon Kolind

Session Number: MIS-09

Parent Session: Looking Beyond Axons: Imaging the Immune System in White Matter

Session Number:MIS-09

Organizers
Julien Cohen-Adad, Francesco Grussu, Shannon Kolind

Overview
This Symposium was proposed by the White Matter study group. Over the past decades, the magnetic resonance (MR) imaging community has largely focused on developing MR biomarkers sensitive and specific to white matter, but focusing mainly on axon morphometry (density, size, orientation) and myelin. But the white matter is much more than that! It also includes numerous glial cells (astrocytes and oligodendrocytes), which are gaining attention in the study of neurodegenerative pathologies and normal development. This symposium provides a neurobiological perspective of non-neural white matter, highlighting the clinical relevance of monitoring this component non-invasively with state-of-the-art MR techniques, with a particular emphasis on its use for imaging the immune system and its interplay with the brain.

Target Audience
Neurologists, radiologists, and physicists interested in imagining non-axonal components in white matter to study the link brain-immune system.

Educational Objectives
As a result of attending this course, participants should be able to:
Upon completion of this course, participants should be able to: - Describe the composition of human white matter, with a focus on non-axonal components; - Name white matter disease conditions that affect the non-neuronal cellular component; - Identify in-vivo MRI techniques for the quantification of non-axonal components in white matter; and - List the advantages, limitations and opportunities of current MRI technology in regard to imaging the immune response.

			The Non-Axonal Component of Human White Matter: What It Is & Why to Image It Caterina Mainero Harvard Medical School
			Imaging Neuroinflammation with Hyperpolarized 13C MRS Myriam M. Chaumeil University of California, San Francisco
			Diffusion-Weighted Magnetic Resonance Spectroscopy: A Tool to Look at Glial Cytomorphology Itamar Ronen Leiden University Medical Centre
			Non-Axonal Contribution to the Diffusion MRI Signal Ileana Jelescu École Polytechnique Fédérale de Lausanne
			Quantitative Magnetisation Transfer Imaging: Not Only Myelin Mara Cercignani Brighton & Sussex Medical School