Nivin N Nyström1, Hanlin Liu2, Francisco Martínez-Santiesteban1, Xiao-an Zhang2, Timothy J Scholl1, and John A Ronald1
1Robarts Research Institute, London, ON, Canada, 2University of Toronto, Toronto, ON, Canada
1Robarts Research Institute, London, ON, Canada, 2University of Toronto, Toronto, ON, Canada
Here, we introduce a Mn(III) porphyrin construct MnTriCP-PhOEt that allows for targeted imaging of cells expressing liver-specific Oatp1 transporters.
Liver Uptake of MnTriCP-PhOEt at 3 Tesla. a) T1-weighted images of a representative mouse before and up to 60 minutes post intraperitoneal injection of 0.025 mmol/kg MnTriCP-PhOEt. b) In vivo signal intensity of various organs over time of a representative mouse. c) Average in vivo signal enhancement of liver (n=3). d) Ex vivo nuclear magnetic relaxation dispersion (NMRD) profiles of various tissues 44 minutes post injection. e) Differences in spin-lattice relaxation rates of various tissues between mice injected 0.025 mmol/kg MnTriCP-PhOEt or saline, 44 minutes post injection.
MnTriCP-PhOEt Structure and Synthesis. a) Molecular structure of MnTriCP-PhOEt. b) 3-dimensional geometry of MnTriCP-PhOEt. q, hydration number. c) Synthesis and yield of MnTriCP-PhOEt. Yields shown in brackets.
