Nazanin Makkinejad1, Ashish A. Tamhane2, David A. Bennett2, Julie A. Schneider2, Boris Gutman1, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States
Combination of ex-vivo MRI and pathology in a large community cohort of older adults revealed unique patterns of deformation of subcortical brain structures associated with different age-related neuropathologies.
Figure 3. Maps of regression coefficients on the subcortical brain structures for the association of the shape measure (Jacobian determinant) with Alzheimer’s pathology, atherosclerosis, and TDP-43 pathology (global FDR correction). Negative coefficients mean inward deformation. The results are shown on the left hemisphere since only one hemisphere was imaged per participant and hence the right hemisphere segmentations were mirrored to left and combined with the rest of the left side segmentations in this analysis.
Figure 1. Demographics and clinical characteristics of the participants
