Yan Li1, Huawei Liu1, Angela Jakary1, Sivakami Avadiappan1, Melanie Morrison1, Ralph Noeske2, Peder E.Z. Larson1, Alexandra Nelson3, Katherine Possin3, Michael Geschwind3, Christopher Hess1, and Janine M Lupo1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2GE Healthcare, Munich, Germany, 3Department of Neurology, University of California San Francisco, San Francisco, CA, United States
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2GE Healthcare, Munich, Germany, 3Department of Neurology, University of California San Francisco, San Francisco, CA, United States
This
study demonstrates the feasibility of using a fast and high-resolution
multi-voxel MRSI at 7T to obtain brain metabolites from patients with PM and EM
at the spatial resolution of 0.5x0.5x2.0cm (0.5cm3) within a
clinical feasible acquisition of 7 minutes.
Figure
1. Example of multivoxel MRS
and ROIs from a patient with pre-manifest HD.
Figure
3. Significant differences
in metabolite ratios between either the PM or EM groups and all of controls
combined (HCEM+HCPM). Metabolites from healthy controls
were plotted for each subgroup (HCEM, HCPM). When
compared to age-/gender-matched healthy controls, only glutathione/creatine
within the insula (EM vs. HCEM, p=0.002) remained significant.