1Cardiovascular Institute, Stanford University, Stanford, CA, United States, 2Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 5Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States
Figure 1: Global and Regional Ecc in
Healthy Boys and LGE(-) boys with DMD. Septal Ecc was significantly lower than anterior, lateral,
and inferior Ecc and the lateral Ecc was significantly higher than septal, anterior,
and inferior Ecc for both the controls or LGE(-) DMD patients. Furthermore, the
LGE(-) DMD patients had significantly reduced septal Ecc compared to healthy
volunteers. *
p-value ≤ 0.05 is significant for a comparison within either controls or LGE(-)
boys with DMD. # p-value
≤ 0.05 is significant for a comparison between controls and LGE(-) patients with
DMD.
Figure 2: Receiver Operator
Characteristic (ROC) curves for septal Ecc, lateral LV pre-contrast T1, and LVEF
from a binomial logistic regression classifier for distinguishing between LGE(-)
boys with DMD from healthy boys. Larger area under the curve (AUC) values indicate better
classifier performance. Regarding differentiating LGE(-) boys with DMD from healthy
boys, septal Ecc outperforms each individual biomarker and the combinaiton of
septal Ecc, lateral LV pre-contrast T1, and LVEF outperforms the other biomarker
combinations.
