0442
A regularized joint water/fat separation and B0 map estimation for 2D-navigated interleaved EPI based diffusion MRI
Yiming Dong1, Kirsten Koolstra2, Malte Riedel3, Matthias J.P. van Osch1, and Peter Börnert1,4
1C.J. Gorter Center for High Field MRI, Department of Radiology, LUMC, Leiden, Netherlands, 2Division of Image Processing, Department of Radiology, LUMC, Leiden, Netherlands, 3University of Lübeck, Lübeck, Germany, 4Philips Research Hamburg, Hamburg, Germany
Applying chemical-shift encoding to msh-EPI can significantly improve fat-suppression and image quality of Diffusion-weighted imaging. The proposed algorithm is able to effectively separate water/fat contents and has been validated using data acquired from healthy volunteers. 
Results of one subject’s lower neck DW msh-EPI at different b-values and the corresponding ADC maps, comparing SPIR, IDEAL, and the proposed method. B0 maps are estimated through b = 0 s/mm2 source images. Both SPIR and IDEAL suffered from severe B0 inhomogeneities in certain regions (marked by red arrows), leaving behind artifacts in both supposed water-only and associated ADC maps. The proposed algorithm mitigates the artifacts and produced more reliable results.
Comparison between IDEAL and the proposed algorithm of one subject’s leg at different b-values. The two B0 maps are estimated from non-diffusion measurements. In the water/fat overlapping regions, IDEAL left rim-like artifacts (marked by red arrows and emphasized in sub-figures at lower level/window) in both water and B0 maps. The proposed eliminates this artifact and produces a better water/fat separation with corrected fat maps locations.