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Quantification of bone marrow edema in RA by using high-speed T2-corrected multiecho acquisition of 1H magnetic resonance spectroscopy
Wenzhao Yuan1, Yiwu Lei1, Cheng Tang1, Fang Qin1, Jing Wen1, Chenhui Li2, Min Ling1, Jiang Huang1, Huiting Zhang3, and Liling Long1
1The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2Siemens Healthcare Ltd., Guangzhou, China, 3Siemens Healthcare Ltd., Wuhan, China
The HISTO sequence could measure the bone marrow FF of the wrist joint.   FF value increased as the DAS28-ESR decreased in RA patients.  The HISTO sequence can monitor the therapeutic effect of RA.
Table 2 Clinical data and HISTO FF values of RA patients at each follow-up time point (mean ± SD) CRP, C-reactive protein; DAS28-ESR, 28-joint disease activity score using erythrocyte-sedimentation rate; ESR, erythrocyte-sedimentation rate; FF, fat fraction; HISTO, high-speed T2-corrected multiecho sequence; PLT, platelet count; RA, rheumatoid arthritis; RF, rheumatoid factor Change 1, the baseline value minus the value at 4 weeks Change 2, the value at 4 weeks minus the value at 8 weeks Change 3, the value at 8 weeks minus the value at 12 weeks
Fig. 2 Trend of the correlation between DAS28-ESR and HISTO values in RA patients during treatment. DAS28-ESR, 28-joint Disease Activity Score using erythrocyte-sedimentation rate; HISTO, high-speed T2-corrected multiecho sequence; FF, fat fraction; RA, rheumatoid arthritis