Yuankui Wu1, Xiaomin Liu1, Jun Hua2,3, Xiaodan Li1, Haimei Cao1, Yingjie Mei4, and Yikai Xu1
1Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Philips healthcare, Guangzhou, China
1Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Philips healthcare, Guangzhou, China
iVASO-derived arteriolar
muscular blood volume (MBVa) decreases with disease progression in DM patients
and has the potential to be used as a useful and sensitive biomarker in
monitoring and diagnosis of DM disease.
Figure 2. Scans from a 30-year-old female healthy
volunteer. Axial T1-weighted image (A) and axial STIR (B). VL = Vastus
lateralis; RF = Rectus femoris; VI = vastus intermedius; VM = Vastus medialis;
AD = adductor magnus; GA = gracilis; BF = biceps femoris; ST = semi-tendinosus.
Axial MBVa map (C) shows the distribution of
arteriolar blood volume in normal muscle. The color scale shows the red end of
the scale indicating an increasing MBVa and the blue end a decreasing MBVa.
Figure 1. Arteriolar blood volume in normal muscles
(N=176), morphologically-normal appearing muscles (MN muscles) (N=67),
edematous muscles (N=86) and atrophic or fat-infiltrated muscles (AF muscles)
(N=47). MBVa_max represents maximum arteriolar muscular blood volume, MBVa_mean
represents mean arteriolar muscular blood volume. *p < 0.05 for MN
muscles, edematous muscles and AF muscles compared to normal muscles. ●p
< 0.001 for AF muscles compared to MN muscles. ■p < 0.001 for AF
muscles compared to edematous muscles.