Hooman Hamedani1, Stephen Kadlecek1, Faraz Amzajerdian1, Ryan Baron1, Kai Ruppert1, Ian Duncan1, Luis Loza1, Tahmina Achekzai1, Maurizio Cereda1, and Rahim R. Rizi2
1University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States
1University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States
The goal
of this ongoing study is to gain a fundamental, quantitative understanding of Treatment
with Zephyr Endobronchial Valves.
Figure
1- A schematic
depiction of the multi-breath sequence (top) in which local signal dynamics of
agent wash-in, washout and response to dissolved species saturation (image
series within colored borders) is quantified to yield a parametric
representation of each voxel’s residual gas volume, ventilation during tidal
breathing, and gas exchange.
Figure
2- Depiction of
the cross-modality registration scheme utilized for quantifying pre/post
functional change. CT images (upper left and 1H MRI (upper middle)
are approximately coregistered using Affine transformations and
Contrast-Limited Adaptive Histogram Equalization (CLAHE, left). The required transformation is then applied
to the HXe image to overlay on the segmented CT (upper right).