0652
Detection of resting state correlations between white matter tracts in spinal cord using BOLD fMRI and their changes with injury
Anirban Sengupta1, Arabinda Mishra1, Feng Wang1, Li Min Chen1, and John C. Gore1
1Vanderbilt University Medical Center, Nashville, TN, United States
Stimulus evoked BOLD fluctuations and correlated resting state BOLD signal was detected robustly in spinal cord WM. Resting state WM correlations followed a trend which mimicked spinal cord functional recovery after an injury. (33 words)  
Figure4: (A) Connectivity matrix (absolute values) averaged over 15 runs of 5 monkeys at different time points (Pre-SCI, Post-SCI Stage1 (2 weeks), Post-SCI Stage2 (7-8 weeks) and Post-SCI Stage3 (16-22 weeks). (B) Box-plot of the connectivity values at different time points . The dotted line joins the median of the box-plots. Significantly different box-plots using Wilcoxon non-parametric test are denoted by * (p<0.05) and ** (p<0.01) .
Figure 5: (A) Mean +/- SD of power spectra (0.01-0.1Hz) of all ICs (averaged over 15 runs of 5 monkeys ) at pre-and post-SCI stage 1. The shaded bar denotes the region where the drop in connectivity is conspicuously observed.(B) Mean of all IC’s power spectra at different time points i.e. pre- and post SCI stage1-3. (C) Box plot of averaged (0.01-0.1 Hz) spectral power for all ICs at different time points. The dotted line joins the median of the box-plots. Statistically significant difference using Wilcoxon non-parametric test are denoted by * (p <.05) and ** (p<.01).