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Hyperpolarised xenon ventilation MRI in difficult asthma; initial experience in a clinical setting

Helen Marshall¹, Grace T Mussell¹, Laurie J Smith¹, Alberto M Biancardi¹, Paul JC Hughes¹, Andrew J Swift¹, Smitha Rajaram¹, Alison M Condliffe¹, Guilhem J Collier¹, Chris S Johns¹, Nick D Weatherley¹, Ian Sabroe², and Jim M Wild¹
¹University of Sheffield, Sheffield, United Kingdom, ²Sheffield Teaching Hospitals, Sheffield, United Kingdom

¹²⁹Xe ventilation MRI can provide additional unique and valuable information in the evaluation of clinical presentations of asthma, when undertaken as part of an MDT evaluation of severe disease.

Figure 2: (A) shows small to moderate sized ventilation defects in a symptomatic patient with consistently normal spirometry. (B) shows relatively homogeneous ventilation in a highly symptomatic patient.

Table 3: Summary of subjects’ MRI classification, spirometry and ACQ7 scores. MRI classified based on radiologists’ reports (normal = no or minor ventilation defects, abnormal = substantial ventilation defects). Note: ACQ7 score was available for 24 patients within 3 months of the scan.