Hyperpolarized 129Xe MRI Ventilation Texture Features to Characterize Long-haul COVID-19 Survivors
Harkiran K Kooner1, Marrissa J McIntosh1, Maksym Sharma1, Alexander M Matheson1, Yasal Rajapaksa1, Inderdeep Dhaliwal2, Michael Nicholson2, and Grace Parraga1
1Robarts Research Institute, Western University, London, ON, Canada, 2Department of Medicine, Western University, London, ON, Canada
129Xe MRI ventilation texture features differentiate long-haul COVID-19 and never-infected participants. This will frame a study of moderate-severe COVID-19 survivors to identify those that may experience long-term symptoms related to COVID-19.
Figure 1: Qualitative results of
ventilation comparison between control group and long-haul COVID-19 patients
Control group participants
S01 and S02 have a VDP of 2% and 1%, respectively, while COVID-19 patients S15
and S16 have a VDP of 3% and 2%, respectively.
Figure 2: MRI ventilation heterogeneity
measurements
Patients with long-haul
COVID-19 have increased VDP (A), short run emphasis (B), high gray-level run
emphasis (C) and short run, high gray-level emphasis (D) extracted from 129Xe
MRI, compared to control group participants.