Lok Hin LAW1, Peng XIAO1, Jianpan Huang1, Xiongqi HAN1, and Kannie WY CHAN1,2,3
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3City University of Hong Kong Shenzhen Research Institute, Shenzhen, China
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3City University of Hong Kong Shenzhen Research Institute, Shenzhen, China
In this study, we investigated the imaging of nanomedicine delivery via intranasal-administration using CEST-detectable mucus penetrating liposome. Ioh-Lipo generated CEST contrast of 33.4% at 4.3 ppm in phantom, which was also observed in-vivo in nostril, OB and FL after Injection at 3T.
Fig.3
In vivo experiment of intranasal administration of 10%-PEG Iohexol Lipo (n=3).
(A) Z-spectra, (B) CESTLDFit plots of CEST contrast at 4.3ppm, (C), T2 image of
ICR mice brain, and (D), (E), (F), (G) CEST map Pre-Injection, and 0.5hr, 1hr,
1.5hr after intranasal injection at 4.3ppm.
Fig.
1 CEST properties of 1%-PEG Ioh-Lipo and 10%-PEG Ioh-Lipo (n=3). (A) Z-spectra
and (B) MTRasym of Ioh-Lipo under 0.9 μT and pH 7.0. (C) was the B1 power
optimization on 10%-PEG Ioh-Lipo.
