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Peritumoral radiomics features from amide proton transfer-weighted MRI unveil the progressive pattern in early recurrent malignant gliomas
Shanshan Jiang1, Pengfei Guo2, Hye Young Heo1, Peter van Zijl1,3, and Jinyuan Zhou1
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
 We explore radiomics features extracted from peritumoral areas on APTw images to unveil the progressive pattern in early recurrent malignant gliomas. Our results suggest that the use of APTw radiomic features can add important value to structural MRI to assess the treatment response.
Fig. 1. Conventional MR images, APTw images and masks for two post-treatment GBM patients. Top case, a patient with tumor recurrence; bottom case, a patient with treatment effects.
Fig. 2. CRT decision tree analysis on the basis of the data from FLAIR, APTw, and both.