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Assessing breast density using the standardized proton density fat fraction based on chemical shift encoding-based water-fat separation
Tabea Borde1, Mingming Wu1, Stefan Ruschke1, Christof Böhm1, Kilian Weiss2, Stephan Metz1, Marcus R Makowski1, and Dimitrios Karampinos1
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Philips Healthcare, Hamburg, Germany
The proton density fat fraction is a useful biomarker of breast water-fat composition that significantly negatively correlates with mammographic breast density and could overcome the reproducibility errors in the reading of mammographic breast density.
Figure 2: Mammograms with breast density estimation following the American College of Radiology Breast Imaging Reporting and Data System categories 1-4 with corresponding PDFF maps.
Figure 3: Correlation of mean PDFF values to the four American College of Radiology Breast Imaging Reporting and Data System categories with adjusted p-values revealing a significant inverse correlation.