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MOdel-free Diffusion-wEighted MRI (MODEM) with Machine Learning for Cervical Cancer Detection
Guangyu Dan1,2, Cui Feng1,3, Zheng Zhong1,2, Kaibao Sun1, Muge Karaman1,2, Daoyu Hu3, and Xiaohong Joe Zhou1,2,4
1Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, 2Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Department of Radiology, Tongji Hospital, Wuhan, China, 4Departments of Radiology and Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States
A model free machine-learning based approach using diffusion signal attenuation signatures can detect cervical cancerous tissues with a high accuracy. Acquisition times can be substantially reduced by using this approach without compromising diagnostic performance. 
Figure 1. Pipeline used in the MODEM machine learning analysis. SMOTE = synthetic minority oversampling technique.
Figure 2. A set of first-order feature maps from one representative patient. The color-coded regions indicate the cancerous and normal ROIs on the diffusion-weighted images with a b-value of 800 s/mm2.