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Reproducibility study of disrupted white matter integrity and partial recovery in children treated for medulloblastoma
Wilburn E Reddick1, Jared J Sullivan1, John O Glass1, Yian Guo2, Julie H Harreld1, Yimei Li2, Giles W Robinson3, Amar Gajjar3, and Thomas E Merchant4
1Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States, 3Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States, 4Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States
FA measures at baseline demonstrated an immediate decline due to tumor and surgery, which is then accentuated by  irradiation followed by a partial recovery, which was attenuated in patients receiving higher doses.
Figure 1: Representative individual dosimetry mapped in cGy onto the TBSS skeleton for an average-risk (A) and high-risk (B) patient.
Figure 5: TBSS results for interaction of dose with longitudinal evolution of the FA after irradiation. The skeleton is shown green overlaid on the average FA with red voxels demarcating significant negative interaction between dose and the positive change over time (slope) indicating that higher doses attenuated the rate of recovery. Distributions of these voxels were primarily in the cerebral peduncles, internal capsule, posterior thalamic radiation, corpus callosum, and corona radiata including the superior longitudinal fasciculus.