Santosh Kumar Bharti1, Raj Kumar Sharma1, Paul T Winnard1, Marie-France Penet1, and Zaver M. Bhujwalla1,2,3
1Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
1Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Identification of systemic metabolic dysregulation
caused by cancer and
cancer-induced cachexia in PDAC cachexia mice model using high-resolution 1H MRS
Figure
1: Representative
1H MR spectra acquired from aqueous phase tissue extracts of spleen
obtained from normal mice and cachectic (Pa04C ) and non-cachectic (Panc1)
tumor bearing mice.
Figure 2: Lung, liver, heart, kidney and spleen weights in
control mice (black) as compared with Panc1 (green) and Pa04C (red) tumor‐bearing mice. In all panels, means of cohorts are
shown as rectangles bar. P-value less that ≤ 0.05 are considered statistically
significant.