1023
Magnetic resonance elastography of the in vivo human brain using multifrequency wavenumber analysis in 2D and 3D.
Helge Herthum1, Heiko Tzschätzsch1, Tom Meyer1, Mehrgan Shahryari1, Lisa Stencel1, Jing Guo1, Jürgen Braun2, and Ingolf Sack1
1Experimentelle Radiologie, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Institut für medizinische Informatik, Charité Universitätsmedizin Berlin, Berlin, Germany
We here present multifrequency wavenumber analysis for MR elastography of the human brain in 2D and 3D. Reproducibility and detail resolution of the new methods are better than obtained from standard multifrequency inversion methods.
Results from MDEV (|G*|) and 2D and 3D k-MDEV (SWS) inversion in different slices (1.5-Tesla). Magnitude images are shown on the left side together with segmented regions for white matter (red) and gray matter (yellow). The last row shows results for the measurement at 3.0-Tesla with 1.6x1.6x2mm3 voxel size. Increased resolution allows to easily identify anatomical regions in deep gray matter characterized by stiff properties such as the putamen and caudate nucleus (indicated by arrows).
2D and 3D k-MDEV. The phase of the MRE data is smoothed (Butterworth lowpass, threshold 250 m-1, order 3) and the harmonic wave field is extracted using the Fourier transform. For 3D, inter-phase discontinuities (IPD) and slice offsets [13] are removed as shown in the sagittal view. A bandpass filter (Butterworth, lower threshold 15 m-1, upper threshold 200 m-1, order 3) suppresses compression waves and the remaining shear wave field is directionally filtered in 8 (2D) or 20 (3D, right, dodecahedron) directions. SWS is reconstructed from the phase gradient in 2D and 3D.